✦ LIBER ✦

Synthesis of tritium labelled mometasone furoate

✍ Scribed by D. Hesk; P. Delduca; D. Koharski; P. McNamara; C. Magatti; S. Saluja; L. Thomas

Book ID: 102369227
Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 133 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330510

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✦ Synopsis

Abstract

^3^H‐mometasone furoate was synthesized by a six step procedure. The label was introduced via the reduction and re‐oxidation of the 1,2 double bond in the A ring. The remaining 4 steps were accomplished with on overall radiochemical yield of 28%. Analysis by ^3^H nmr indicated that most of the label (≈95%) was located in the 2‐position and the remainder in the 1‐position.

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