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Synthesis of tritium labelled 24-epibrassinolide

✍ Scribed by A. Kolbe; V. Marquardt; G. Adam

Book ID: 102368549
Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 252 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580311010

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✦ Synopsis

Abstract

Deuterium and tritium 5,7,7‐tris‐labelled 24‐epibrassinolide were prepared by base catalyzed exchange reaction using 24‐epicastasterone tetraacetate 1 or bis‐isopropylidenedioxy‐24‐epicastasterone 8 and labelled water. Baeyer‐Villiger oxidation of the obtained labelled 6‐ketones 2 and 3 with CF~3~CO~3~H gave after alkaline deacetylation of the resulting 4 and 5 the desired tris‐labelled 24‐epibrassinolides 6 and 7, respectively, or starting from 9 under simultaneous oxidation and deprotection in one step the same final products.

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