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Synthesis of tritium labeled Ac-[Nle4, D-Phe7]-α-MSH4−11-NH2: A superpotent melanotropin with prolonged biological activity

✍ Scribed by Brian C. Wilkes; Victor J. Hruby; Henry I. Yamamura; Kazufumi Akiyama; Ana Marie de L. Castrucci; Mac E. Hadley; Joseph R. Andrews; Y.-P. Wan

Book ID: 118340423
Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 368 KB
Volume: 34
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(84)90302-3

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Analogs of Ac-[Nle4]-cr-MSH4.,,-NH2 and Ac-[Nle4, D -P ~~~] -~-M S H ~. , , -N H ~ were prepared with D-kOtneriC replacements at the His', Arg', and Trpg residues. The requirement for an indole moiety at position 9 also was evaluated by replacement with L-leucine in both parent fragment analogs. D-i