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Potent and prolonged melanotropic activities of the α-MSH fragment analog, Ac-[Nle4, D-Phe7]-α-MSH4–9-NH2

✍ Scribed by David G. Klemes; Kristie L. Kreutzfeld; Mac E. Hadley; Wayne L. Cody; Victor J. Hruby


Book ID
115759937
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
371 KB
Volume
137
Category
Article
ISSN
0006-291X

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✍ L. C. Panasci; A. McQuillan; M. Kaufman 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 731 KB

The alpha-MSH (alpha-melanocyte-stimulating hormone) agonist, Ac-[Nle4, D-Phe7]alpha-MSH4-11NH2 (hereafter called ND4-11 alpha-MSH), is at least 10-fold more potent than alpha-MSH as a stimulus of tyrosinase activity in F1 variant cells of B16 melanoma. The binding to these cells during an incubatio