✦ LIBER ✦

Synthesis of tritium labeled 1-methyl-4-[4-(7-trifluoromethyl-4-quinolyl)-aminobenzoyl]piperazine and derivatives

✍ Scribed by Richard S. P. Hsi

Publisher: John Wiley and Sons
Year: 1976
Tongue: French
Weight: 440 KB
Volume: 12
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580120418

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✦ Synopsis

Abstract

Deuteration of p‐aminobenzoic acid hydrochloride (PAB·HCl) was studied to provide a model for tritiating PAB‐HCl. Tritium labeled PAB·HCl was used as the starting material for the synthesis of tritium labeled 1‐methyl‐4‐[4‐(7‐trifluoromethyl‐4‐quinolyl)aminobenzoyl]piperazine (Ic) and the corresponding 1‐demethyl compound (Id) and 1‐oxide (II).

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