## 3804 with NaH provided the pyrrolidone in which the Boc group was cleaved under the reaction conditions. This group was reintroduced with Boc20 to give 7 [87% from 3, oil, [a]D -62.2" (c 1.23, CHCl3)]. Unsaturated 8 was prepared using the reported method. 7 Cyclopropanation of 4 and 8 was carri
Synthesis of trans and cis-α-(carboxycyclopropyl)glycines. Novel neuroinhibitory amino acids as L-glutamate analogue
✍ Scribed by Keiko Yamanoi; Yasufumi Ohfune; Kazuko Watanabe; Philipp Novales Li; Hiroshi Takeuchi
- Book ID
- 104220187
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 266 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Novel Enantioselective Synthesis of trans-α-(2-Carboxycycloprop-1yl)glycines: Conformationally Constrained L-Glutamate Analogues. -Key step of the described sequence is the oxazaborolidine-catalyzed enantioselective conversion of oxime ethers (V) and (VI) to the corresponding amines. Interestingly,
Pyroglutamic acid derivative (I) is proved to be an excellent chiral starting compound for the synthesis of title amino acids (IX), (X), and (V). The syntheses are based on a combination of methods previously used for the preparation of 4-and 5-substituted prolines. These methods are the ring openin
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