A synthesis of ceramide analogs 6 and 7 is reported here starting from L-cysteine. Alkylation of 2 and subsequent reduction of the intermediate formed ketone 3 afforded the diitereomeric alcohols 4. Deprotection and acylation of 4 lead to the desired product 6 which is converted to the sulfonium sal
Synthesis of three potential inhibitors of the biosynthesis of leukotrienes A–E
✍ Scribed by E.J. Corey; Hokoon Park; Alan Barton; Yasushi Nii
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 250 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Simple synthetic routes arc described to 5,6_dehydroarachidnnic acid (5). cis-8-eicosen-5-ynoic acid (6) and the thio analog of ('I-leukotriene A (71,which are of value in the study of ^ inhibition of the biosynthesis
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