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Synthesis of new substituted quinolizidines as potential inhibitors of ergosterol biosynthesis

✍ Scribed by Alain Godard; Philippe Lamour; Pierre Ribereau; Guy Quéguiner


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
602 KB
Volume
51
Category
Article
ISSN
0040-4020

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A synthesis of ceramide analogs 6 and 7 is reported here starting from L-cysteine. Alkylation of 2 and subsequent reduction of the intermediate formed ketone 3 afforded the diitereomeric alcohols 4. Deprotection and acylation of 4 lead to the desired product 6 which is converted to the sulfonium sal