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Synthesis of potential inhibitors of the glycosphingolipid biosynthesis

✍ Scribed by Gerald Brenner-Weiß; Athanassios Giannis; Konrad Sandhoff

Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
523 KB
Volume
48
Category
Article
ISSN
0040-4020

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✦ Synopsis

A synthesis of ceramide analogs 6 and 7 is reported here starting from L-cysteine. Alkylation of 2 and subsequent reduction of the intermediate formed ketone 3 afforded the diitereomeric alcohols 4. Deprotection and acylation of 4 lead to the desired product 6 which is converted to the sulfonium salt 7. ~orn~o~d 6 is a powerful inhibiir of the gly~spb~iipid biosynthesis.

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Synthesis of three potential inhibitors
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✍ E.J. Corey; Hokoon Park; Alan Barton; Yasushi Nii 📂 Article 📅 1980 🏛 Elsevier Science 🌐 French ⚖ 250 KB

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