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Synthesis of the Phosphoramidite Derivatives of 2‘-Deoxy-2‘-C-α-methylcytidine and 2‘-Deoxy-2‘-C-α-hydroxymethylcytidine: Analogues for Chemical Dissection of RNA's 2‘-Hydroxyl Group

✍ Scribed by Li, Nan-Sheng; Piccirilli, Joseph A.


Book ID
111924534
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
272 KB
Volume
69
Category
Article
ISSN
0022-3263

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Stereoselective synthesis of s-(2-deoxy-
✍ Joanna Borowiecka; Paweł Lipka; Maria Michalska 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 623 KB

Addition oP C,F'-dialkylphosphorodithioic acids to fully protected 1,2-unsaturated hsxo-and pentopyranoses gives S-(2-deoxy-glycosyl)-phosphorodithioates 'P -OH RO' 'SH -# H /OR HS-l'OR 2 2 Scheme I 2oa the &\_-adducte. The observed Oc'/s ratio was 89:ll and 92:8, respectively. pllso in these cases