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Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.

✍ Scribed by Neville J. Anthony; Trafford Clarke; A. Brian Jones; Steven V. Ley

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 241 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96833-3

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✦ Synopsis

The efficient synthesis of C-l to C-10 monocyclic nonaromatic fragments of the milbemycins and avermectins has been achieved, in which the key step involved the stereoselective addition of 2-lithio-4-phenylthiobut-1-ene to a 3-hydroxycyclohexanone derivative.

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