ChemInform Abstract: Total Synthesis of Milbemycin E: Resolution of the C(1)-C(10) Fragment and Final Assembly.

✍ Scribed by P. G. STEEL; O. S. MILLS; E. R. PARMEE; E. J. THOMAS

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199729240

✦ Synopsis

Total Synthesis of Milbemycin E: Resolution of the C(1)-C(10) Fragment and Final Assembly. -Resolution of the cyclohexanone (I) is the starting process in the preparation of title compound (VI). Key step is the coupling of butenolide (II) with phosphonium salt (III) (both prepared in the preceding papers) which allows introduction of the labile 3,4-double bond in an early stage of the synthesis.