𝔖 Bobbio Scriptorium
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Synthesis of the marine alkaloid leucettamine B

✍ Scribed by Nathalie Roué; Jan Bergman

Book ID
104209746
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
645 KB
Volume
55
Category
Article
ISSN
0040-4020

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✦ Synopsis

The marine natural product leucettamine B 2 has been prepared in good yield via two different routes, starting with glycine or with 3-methyl thiohydantoin, involving simple aldol condensation, and finally transamination of the thiohydantoin derivative.

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Microwave-mediated solventless synthesis
Microwave-mediated solventless synthesis of new derivatives of marine alkaloid Leucettamine B
✍ Jean-René Chérouvrier; François Carreaux; Jean Pierre Bazureau 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 85 KB

New access to N-alkyl derivatives of the marine alkaloid Leucettamine B are described using two three-step convergent routes. For the formation of the 2-amino imidazolone ring, the key steps involve solvent-free condensations under microwaves and guanylation reactions with non-sterically hindered pr