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Microwave-mediated solventless synthesis of new derivatives of marine alkaloid Leucettamine B

✍ Scribed by Jean-René Chérouvrier; François Carreaux; Jean Pierre Bazureau

Book ID
104250993
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
85 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

New access to N-alkyl derivatives of the marine alkaloid Leucettamine B are described using two three-step convergent routes. For the formation of the 2-amino imidazolone ring, the key steps involve solvent-free condensations under microwaves and guanylation reactions with non-sterically hindered primary amines.

📜 SIMILAR VOLUMES

Synthesis of the marine alkaloid leucett
Synthesis of the marine alkaloid leucettamine B
✍ Nathalie Roué; Jan Bergman 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 645 KB

The marine natural product leucettamine B 2 has been prepared in good yield via two different routes, starting with glycine or with 3-methyl thiohydantoin, involving simple aldol condensation, and finally transamination of the thiohydantoin derivative.