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Synthesis of the macrolide antibiotic A26771B methyl ester

✍ Scribed by T.A. Hase; E.-L. Nylund

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
210 KB
Volume
20
Category
Article
ISSN
0040-4039

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✦ Synopsis

The total synthesis of the title compound (1) is reported.

The isolation and structure elucidation of the 16-membered lactone antibiotic A2677lB (1) from PeniciZZium turbatum (Westling) was recently reportedl.

The compound shows optical activity but its absolute (and relative) stereostructure is unknown at present. We report here the total synthesis of (+)-I methyl ester and its diastereomer, based on the strategy of combining a saturated Cl1

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The total synthesis of a sixteen-membered macrocyclic lactone antibiotic, A26771B and its absolute configuration are described by using D-glucose as a chiral source. A 16-membered macrocyclic lactone antibiotic A26771B (&), p reduced by PeraiciZZium turbatwn,