𝔖 Bobbio Scriptorium
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Synthesis of the glycosyl phosphatidyl inositol anchor of rat brain Thy-1

✍ Scribed by Denis Tailler; Vincent Ferrières; Klaus Pekari; Richard R. Schmidt

Book ID
104260547
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
275 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Disintegration of the target molecule 1 into building blocks A-E was performed. For D, an efficient synthesis of mannose derivative 5, representing mannose residue c in the target molecule, could be performed; 5 permits the required regioselective access to C-I, 2-0, 4-0, and 6-0. Reaction of 5 with galactosamine donor 3 led to D in high yield. E could be readily prepared from known mannosyl donors 7 and 9. Combination of A-E led to the fully O-benzyl protected target molecule 14 in only eleven highyielding steps, thus exhibiting the efficiency of this convergent strategy, which provides target molecule 1.

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