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Synthesis of the epimeric 2-bromocholesterols and their conversion into (2α-3H)cholesterol and [2ß-3H]cholesterol

✍ Scribed by J. Römer; H. Wagner; K. Ponsold

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
398 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

The s y n t h e s i s of t h e epirceric 2-bromocbolesterols is d e s c r i b e d . T h e i r r e d u c t i v e c a t a l y z e d debromination w i t h T2 a f f o r d s c20<-'HJa.nd [2B -311]cbolesterol r e s p e c t i v e l y . The [Z -3E]cholesterols c a n be s y n t h e s i s e d w i t h a r a d i o c h e m i c a l pul'ity >98% aiid s p e c i f i c e c t i v i t i e s of about 600 -700 GSq/mmol. The l a b e l l i n g r e a c t i o n s proceed under r e t e n t i o n .

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