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Synthesis of 2-furanylmethyl-α-2H and -3H furosemide

✍ Scribed by W. L. Nelson; P. J. Wirth; C. J. Bettis; L. A. Spitznagle

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
165 KB
Volume
11
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Synthesis of furosemide. specifically labelled at the 2‐furanylmethyl α‐position with ^2^H or ^3^H is reported. This synthesis required reduction of N‐[(2‐furanyhethyl)amino]‐4‐chloro‐5‐(N‐acetylaminosulfonyl)benzoia acid (2) with sodium ^2^H‐ or ^3^H‐borohydride. followed by alkaline hydrolysis of the acetyl group.

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