✦ LIBER ✦

Synthesis of the diuretic 8-chloroalloxazine-5,10-dioxide

✍ Scribed by H. G. Petering; G. J. van Giessen

Publisher: John Wiley and Sons
Year: 1963
Tongue: English
Weight: 107 KB
Volume: 52
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600521223

No coin nor oath required. For personal study only.

✦ Synopsis

In the preparation of the higher homologs, a slight excess of cyclopropylamine was used. Distillation of the resultant products of reduction was uncomplicated.

N-1sopropylcyclopropylamine.-C yclopropylamine (28.5 Gm.. 0.5 mole) and 31.8 Gm. (0.5 mole) of acetone were mixed and allowed to stand for 1 hour, then hydrogenated under 2-3 atm. pressure in the presence of 1.0 Gm. of platinum oxide. After uptake of hydrogen was complete (6 hours), the mixture was allowed to stand until the REFERENCES

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