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Synthesis of the cyclohexyl fragment of FK-506 by intramolecular ene-reaction

✍ Scribed by Martin E. Maier; Bäbel Schöffling


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
257 KB
Volume
31
Category
Article
ISSN
0040-4039

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Stereoselective synthesis of the C10C24
✍ Zhaoyin Wang 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 267 KB

A highly stereoselective route to the CIO-CZ~ fragment of FK-506 is described. ## Recently the potent immunosuppressant FK-506 was isolated from Streptomyces tsukuaensis and its structure was assigned as the novel 23-membered macrocyclic lactone 1.1 The activity of this unique macrolide is report