Stereoselective synthesis of the C10C24
✍
Zhaoyin Wang
📂
Article
📅
1989
🏛
Elsevier Science
🌐
French
⚖ 267 KB
A highly stereoselective route to the CIO-CZ~ fragment of FK-506 is described. ## Recently the potent immunosuppressant FK-506 was isolated from Streptomyces tsukuaensis and its structure was assigned as the novel 23-membered macrocyclic lactone 1.1 The activity of this unique macrolide is report