A highly stereoselective route to the CIO-CZ~ fragment of FK-506 is described. ## Recently the potent immunosuppressant FK-506 was isolated from Streptomyces tsukuaensis and its structure was assigned as the novel 23-membered macrocyclic lactone 1.1 The activity of this unique macrolide is report
✦ LIBER ✦
An enantioselective synthesis of the C(10) to C(20) fragment of FK506
✍ Scribed by Martin E Maier; Bärbel Schöffling
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 297 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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