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Synthesis of the C20–C32 Tetrahydropyran Core of the Phorboxazoles and the C22 Epimer via a Stereodivergent Michael Reaction

✍ Scribed by Clarke, Paul A.; Ermanis, Kristaps


Book ID
120372556
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
369 KB
Volume
14
Category
Article
ISSN
1523-7060

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Studies on the synthesis of the anticancer natural products, the phorboxazoles, have led to the synthesis of the C21-C32 penta-substituted tetrahydropyran core which is epimeric to the natural product at C23. The synthesis was achieved in only seven linear steps. The key steps were the use of a Masa

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