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Towards the total synthesis of phorboxazoles A and B: Stereocontrolled synthesis of a C20C32 subunit

✍ Scribed by Ian Paterson; Euan A. Arnott

Book ID
108387017
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
260 KB
Volume
39
Category
Article
ISSN
0040-4039

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The tetrahydropyranone 3, representing a pentacyclic C 4 -C 32 segment of the phorboxazoles, was obtained by a complex hetero Diels-Alder (HDA) coupling performed between the 2-siloxydiene 23 and the oxazole aldehyde 4, mediated by the chiral tridentate Cr(III) catalyst 14. In preliminary studies, t