## Abstract **The cover picture shows** the intermolecular interactions between the marine‐derived dictyostatin and the β‐tubulin binding site, as well as some important molecular fragments of the required 15‐step sequence to produce the C11–C23 fragment (highlighted in blue) of dictyostatin in goo
Synthesis of the C11–C23 Fragment of the Potent Antitumor Agent Dictyostatin
✍ Scribed by Luiz C. Dias; Dimas J. P. Lima; Caroline C. S. Gonçalves; Adriano D. Andricopulo
- Book ID
- 102177062
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 133 KB
- Volume
- 2009
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Abstract
We wish to report here our initial efforts toward the total synthesis of the potent antitumor agent dictyostatin, describing a short and efficient synthesis of the C11–C23 fragment. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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A stereocontrolled synthesis of the C15±C27 fragment of laulimalide is described. Key features are a divergent±convergent synthesis from (R)-glycidol, an interesting formation of a trisubstituted double bond via ring closing metathesis with Grubbs' ruthenium catalyst and a site selective protection