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Synthesis of the C15–C27 fragment of the antitumor agent laulimalide

✍ Scribed by E.Kate Dorling; Elisabeth Öhler; Johann Mulzer

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
129 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereocontrolled synthesis of the C15±C27 fragment of laulimalide is described. Key features are a divergent±convergent synthesis from (R)-glycidol, an interesting formation of a trisubstituted double bond via ring closing metathesis with Grubbs' ruthenium catalyst and a site selective protection of a syn-1,2-diol.

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