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Synthesis of the C10−C32 Core Structure of Spirangien A

✍ Scribed by Lorenz, Michael; Kalesse, Markus

Book ID
121424361
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
114 KB
Volume
10
Category
Article
ISSN
1523-7060

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✍ Ian Paterson; Alison D. Findlay; Edward A. Anderson 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 1 views

Spirangiens A (1, Scheme 1) and B (2), [1] isolated by the research group of Höfle from the epothilone-producing myxobacterium Sorangium cellulosum (strain So ce90), are polyketide metabolites [2] that possess potent antifungal and cytotoxic activity (IC 50 0.7 ng mL À1 against L929 mouse fibroblast