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Synthesis of the 5′-triphosphate of a trimer containing 2′-5′-internucleotide linked riboadenosines

✍ Scribed by J. A. J. den Hartog; J. Doornbos; R. Crea; J. H. van Boom

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
171 KB
Volume
98
Category
Article
ISSN
0165-0513

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A general synthesis of 2'-5' linked oligoribonucleotides has been achieved on the basis of chemoselective formation of the 2'-5' internucleotide linkage using N-unblocked nucleosides. The 2'-5' linked oligoadenylates (2-5As) produced from ATP in the