✦ LIBER ✦

Synthesis of the (3 R ,6 S )-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

✍ Scribed by Burgey, Christopher S.; Paone, Daniel V.; Shaw, Anthony W.; Deng, James Z.; Nguyen, Diem N.; Potteiger, Craig M.; Graham, Samuel L.; Vacca, Joseph P.; Williams, Theresa M.

Book ID: 121506337
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 127 KB
Volume: 10
Category: Article
ISSN: 1523-7060
DOI: 10.1021/ol8011524

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Potent, Orally Bioavailable Calcitonin G

Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N -[(3 R ,6 S )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

✍ Paone, Daniel V.; Shaw, Anthony W.; Nguyen, Diem N.; Burgey, Christopher S.; Den 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 54 KB

Pharmacological Characterization of MK-0

Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

✍ Salvatore, C. A.; Hershey, J. C.; Corcoran, H. A.; Fay, J. F.; Johnston, V. K.; 📂 Article 📅 2007 🏛 American Society for Pharmacology and Experimental 🌐 English ⚖ 370 KB

Practical Diastereoselective Synthesis a

Practical Diastereoselective Synthesis and Scale-up Study of (+)-2-((1 R ,2 R ,3 R ,5 S )-2-Amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)ethanol: A Key Intermediate of the Novel Prostaglandin D 2 Receptor Antagonist S-5751

✍ Hida, Takemasa; Mitsumori, Susumu; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Hash 📂 Article 📅 2009 🏛 American Chemical Society 🌐 English ⚖ 243 KB

Discovery of (5 S ,6 S ,9 R )-5-Amino-6-

Discovery of (5 S ,6 S ,9 R )-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5 H -cyclohepta[ b ]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine

✍ Luo, Guanglin; Chen, Ling; Conway, Charles M.; Denton, Rex; Keavy, Deborah; Sign 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 549 KB

Synthesis and Biological Evaluation of M

Synthesis and Biological Evaluation of Metabolites of 2- n -Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9 H -purin-6-ylamine (ST1535), A Potent Antagonist of the A 2A Adenosine Receptor for the Treatment of Parkinson’s Disease

✍ Piersanti, Giovanni; Bartoccini, Francesca; Lucarini, Simone; Cabri, Walter; Sta 📂 Article 📅 2013 🏛 American Chemical Society 🌐 English ⚖ 537 KB

Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-d

Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure

✍ Degnan, Andrew P.; Chaturvedula, Prasad V.; Conway, Charles M.; Cook, Deborah A. 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 463 KB