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Synthesis of the 14C-labelled juvenoid W328

✍ Scribed by Tomas Elbert; Libor Havlicek; Zdenek Wimmer; Marianne Bubner

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 271 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580340409

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✦ Synopsis

Abstract

The labelled juvenoid 2‐(4‐(2‐(ethoxycarbamatoethoxy)(benzene‐U‐^14^C)benzyl) ‐1‐cyclohexanone ethylene acetal (8) (W 328) was prepared starting from p‐hydroxy(ring‐U‐^14^C)benzoic acid (1) by a seven step synthesis in 11% overall yield. The reaction conditions previousiy reported for the „coid”︁ synthesis of the W 328 (8) were modified to suit the small scale preparation.

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