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Synthesis of tetradeuterated buspirone

✍ Scribed by D. D. Dischino; R. R. Covington; C. M. Combs; R. E. Gammans

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 337 KB
Volume: 25
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580250403

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✦ Synopsis

Two methods have been developed for the synthesis of tetradeuterated buspirone. reaction of 1-(2-pyrimidinyl)piperazine-3,3,5,5-d4 or 1-(2-pyrirnidinyl). piperazine-2,2,3,3, -d, with 8-(bromobutyl)-8-azaspiro( 4.5]decane-7,9dione in refluxing acetonitrile.

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