Synthesis of technetium-99m labeled diaminodithiol for bifunctional chelating agents
β Scribed by K. Shiba; H. Mori; H. Matsuda; S. Tsuji; K. Kinuya; K. Hisada
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 628 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0883-2889
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A novel bifunctional chelate, 1, was designed and synthesized for labeling of proteins and small molecules with technetium-99m. The new chelate contains a free carboxyl group which is available for covalent attachment to free amino groups on biologically-important molecules. The resulting chelator
## Abstract Owing to its optimal nuclear properties, ready availability, low cost and favourable dosimetry, ^99m^Tc continues to be the ideal radioisotope for medicalβimaging applications. Bifunctional chelators based on a tetraamine framework exhibit facile complexation with Tc(V)O~2~ to form mono
Recently, technetium-99m (99mTc) labeling of proteins through the use of a bifunctional chelating agent (BCA) has been reported. In previous work, a BCA containing a di(N-methylthiosemicarbazone) (DTS) moiety for 99mTc has offered good potential; however, conjugation with bulky proteins has induced