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Synthesis of a novel diaminodithiol ligand for labeling proteins and small molecules with technetium-99m

✍ Scribed by Hemant K. Misra; Frank Virzi; Don J. Hnatowich; George Wright

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 249 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)99604-7

No coin nor oath required. For personal study only.

✦ Synopsis

A novel bifunctional chelate, 1, was designed and synthesized for labeling of proteins and small molecules with technetium-99m.

The new chelate contains a free carboxyl group which is available for covalent attachment to free amino groups on biologically-important molecules.

The resulting chelator may bind reduced technetium-99m such that the label is stable in vitro and in vivo.

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