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Synthesis of taxoids 3. A novel and efficient method for preparation of taxoids by employing cis-glycidic acid

โœ Scribed by Tetsuo Yamaguchi; Naoyuki Harada; Kunihiko Ozaki; Tomiki Hashiyama

Book ID
104259584
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
232 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A novel route for the synthesis of docetaxel (2) using esterification of (2R, 3R)glycidic acid with 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Subsequent stereo-and regio-selective conversion afforded 2 and related novel compounds.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of taxoids 4. Novel and versat
Synthesis of taxoids 4. Novel and versatile methods for preparation of new taxoids by employing cis- or trans-phenyl glycidic acid
โœ Tetsuo Yamaguchi; Naoyuki Harada; Kunihiko Ozaki; Masahito Hayashi; Hiroaki Arak ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 907 KB

A novel route to the synthesis of docetaxel using esterification of (2R,3R)or (2R, 3S)-glycidic acid with 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Related novel taxoids which have new side chains were synthesized from these synthetic intermediates.