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A Novel Method for the Preparation of α,α′-Difluoroesters and Acids Using BrF3.

✍ Scribed by Aviv Hagooly; Revital Sasson; Shlomo Rozen


Publisher
John Wiley and Sons
Year
2004
Weight
127 KB
Volume
35
Category
Article
ISSN
0931-7597

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A Novel Synthetic Approach to the Preparation of Various α,. alpha.-Difluoroesters. -Successive condensation of ethyl bromofluoroacetate with thiophenol and aldehydes provides α-fluoro-β-hydroxy-α-phenylthio esters (I). Treatment of these esters with exception of (Id) with DAST yields rearranged α,