Synthesis of tanshinone-II and cryptotanshinone
โ Scribed by H. Kakisawa; M. Tateishi; T. Kusumi
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- French
- Weight
- 176 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0040-4039
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## Abstract 8,8โDimethylโ5,6,7,8โtetrahydrophenanthreneโ3,4โdione (3) and 8,8โdimethylโ2โ(lโhydroxy ethyl)โ5,6,7,8โtetrahydrophenanthreneโ3,4โdione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active
A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotan