Synthesis and Antitumor Activity of Tanshinone Analogues

✍ Scribed by Aisa; Haji Akber; Wd Lu; Jun-Chao Cai

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 180 KB
• Volume: 21
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.20030210703

✦ Synopsis

Abstract

8,8‐Dimethyl‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (3) and 8,8‐dimethyl‐2‐(l‐hydroxy ethyl)‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P‐388 cell line as assayed by in vitro MTT method.