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Synthesis and vasodilative activity of tanshinone IIA derivatives

✍ Scribed by Yue-Feng Bi; Hai-Wei Xu; Xiao-Qing Liu; Xiao-Juan Zhang; Zhen-Ji Wang; Hong-Min Liu

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 280 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.076

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✦ Synopsis

A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotanshinone (D(2)) were also prepared in this work. Vasodilation activity in vitro of them was valuated on the contractile response of vascular thoracic aorta smooth muscle from Wistar rats for the first time. Most of them exhibited a concentration-dependent inhibition on the contractile response of norepinephrine.

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