SYNTHESIS OF t -BUTYL ESTER OF 7-AMINOCEPHALOSPORANIC ACID
β Scribed by Mangia, Alberto; Scandroglio, Angelo; Buttero, Paola Del
- Book ID
- 121263895
- Publisher
- Taylor and Francis Group
- Year
- 1986
- Tongue
- English
- Weight
- 131 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0030-4948
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π SIMILAR VOLUMES
Enantioselective syntheses of optically active or-amino acids from glycine t-butyl ester through Schiff base employing (+)-N-alkyl-10-camphorsulfonamides as chiral auxiliaries were described. Methylation of Schiff base 5 gave high asymmetric inductions, whereas ethylation, allylation and benzylation
respect to the position of the double bond in the Scheme
## Abstract In this paper the synthesis and some properties of NβphthaloylβLβserineβt.butylester are described.
+)-7-Aminocephalosporanic acid (18a) and (+)-7-epi-aminocephalosporanic acid (4a) have been synthesized. A chiral HPLC method has been developed for the separation of the four stereoisomers. Natural (+)-7-aminocephalosporanic acid (1) was demonstrated to be enantiomerically (ee >> 99.95%) and diaste