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Synthesis of stable isotope-labelled analogs of the cysteine and N-acetylcysteine conjugates of tetrachloroethylene

✍ Scribed by Michael J. Bartels; Virginia W. Miner

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
255 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Stable isotope‐labelled analogs of the cysteine and N‐acetylcysteine conjugates of tetrachloroethylene have been prepared. S‐(1,2,2‐Trichlorovinyl)‐DL‐cysteine‐3,3‐^2^H~2~ was synthesized in a rapid, one‐step procedure from tetrachloroethylene and DL‐cysteine‐3,3‐^2^H~2~. Unlabelled S‐(1,2,2‐trichlorovinyl)‐L‐cysteine was prepared in a similar fashion. The corresponding ^13^C‐N‐acetyl‐S‐(1,2,2‐trichlorovinyl)cysteine compounds were then prepared via acetylation of the deuterated and unlabelled cysteine conjugates with ^13^C‐acetyl chloride.

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