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Synthesis of spiro-annelated pyroglutamides by the Ugi reaction

✍ Scribed by Stolyarenko, Vasiliy Yu.; Evdokimov, Anatoliy A.; Shishkin, Vladimir I.


Book ID
122793160
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
514 KB
Volume
23
Category
Article
ISSN
0959-9436

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The Ugi four-component condensation between 5-oxo-3-thiacarboxylic acids, benzylamines and cyclohexyl isocyanide gave 5-oxothiomorpholine-3-carboxamides. The configuration of bicyclic thiomorpholine derivatives was established by NOESY experiments.