✦ LIBER ✦

Synthesis of specifically-labelled tritiated benzimidazole carbamates

✍ Scribed by E. Lacey

Publisher: John Wiley and Sons
Year: 1985
Tongue: French
Weight: 367 KB
Volume: 22
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580220904

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✦ Synopsis

Benzimidazole carbamates are thought to exert their biological activity as anthelmintics by binding to helminth tubulin.

To investigate this hypothesis, the synthesis of two specifically-labelled tritlated benzimidazoles, parbendazole and oxibendazole, has been accompliahed. These labels were prepared by debrominatlon of the appropriate 5-bromo analogue using sodium borotritlde in the presence of palladlum chloride. The bromlnated derivatives were syntheslsed by the bromination of the benzimldazole using bromine in glacial acetic acid.

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