Synthesis of some substituted triazolo[4,3-b][1,2,4]triazines as potential anticancer agents
✍ Scribed by Ibrahim M. Labouta; Nabil H Eshba; Hassan M. Salama
- Book ID
- 104951285
- Publisher
- Springer Vienna
- Year
- 1988
- Tongue
- English
- Weight
- 264 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0026-9247
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A series of triazines have been synthesized starting from 5-alkyl-1,3,4-thiadiazole-2-thioles (1a-d). On reaction with ethyl bromoacetate in the presence of anhydrous K 2 CO 3 under microwave irradiation (MWI), these yielded corresponding esters (2a-d) which on hydrazinolysis under MWI produced (5-a
## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐