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Microwave-Assisted Synthesis of Novel 1,3,4-Thiadiazolyl-Substituted 1,2,4-Triazines as Potential Antitubercular Agents

✍ Scribed by Mazaahir Kidwai; Rajesh Kumar; Anil Srivastava; H.P. Gupta

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
196 KB
Volume
26
Category
Article
ISSN
0045-2068

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✦ Synopsis

A series of triazines have been synthesized starting from 5-alkyl-1,3,4-thiadiazole-2-thioles (1a-d). On reaction with ethyl bromoacetate in the presence of anhydrous K 2 CO 3 under microwave irradiation (MWI), these yielded corresponding esters (2a-d) which on hydrazinolysis under MWI produced (5-alkyl-1,3,4-thiadiazol-2-yl sulfanyl) acetohydrazides (3a-d). The reaction of 3a-d with ΝΆ-bromoacetophenone under MWI yielded 6-aryl-3-[(5alkyl-1,3,4-thiadiazol-2-yl sulfanyl)methyl]-1,2,4-triazines (4a-h). All the synthesized triazines showed in vitro antitubercular activity.

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✍ Dong-Qing Wu; Jian-Li He; Jun-Ke Wang; Xi-Cun Wang; Ying-Xiao Zong πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons βš– 26 KB πŸ‘ 2 views

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