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Synthesis of some cis- and trans-2-dimethylaminomethyl cyclic amines and related diamines

โœ Scribed by Hine, Jack; Li, Wu-Shyong


Book ID
127051844
Publisher
American Chemical Society
Year
1975
Tongue
English
Weight
576 KB
Volume
40
Category
Article
ISSN
0022-3263

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A stereoselective approach to the synthesis of cis-and trans-3-fluoro-1-phenylcyclobutylamine has been developed. Excellent stereoselectivity was obtained by the reduction of the appropriately substituted cyclobutanone to give either cis-or trans-isomers of 3-hydroxyl-1-phenylcyclobutylamine, which