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Stereoselective synthesis of cis- and trans-3-fluoro-1-phenylcyclobutyl amine

✍ Scribed by Pengcheng P. Shao; Feng Ye

Book ID: 104095304
Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 119 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.04.018

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✦ Synopsis

A stereoselective approach to the synthesis of cis-and trans-3-fluoro-1-phenylcyclobutylamine has been developed. Excellent stereoselectivity was obtained by the reduction of the appropriately substituted cyclobutanone to give either cis-or trans-isomers of 3-hydroxyl-1-phenylcyclobutylamine, which was stereoselectively converted to the 3-fluoro derivative.

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