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Synthesis of small and medium sized 2,2-disubstituted lactams via the “intramolecular” three component Ugi reaction

✍ Scribed by Geraldine C.B. Harriman


Book ID
104257619
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
169 KB
Volume
38
Category
Article
ISSN
0040-4039

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ChemInform Abstract: Synthesis of Small
✍ G. C. B. HARRIMAN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

Synthesis of Small and Medium Sized 2,2-Disubstituted Lactams via the " Intramolecular" Three Component Ugi Reaction. -Tethered keto-acids undergo an intramolecular three-component Ugi reaction with a variety of primary amines and isocyanates to form five-to eight-membered lactams in good yields. -(

The synthesis of aza-β-lactams via tande
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The synthetic utility of a tandem Petasis-Ugi multi-component condensation and 1,3-diisopropylcarbodiimide condensation reactions have been employed to efficiently prepare two to four-dimensional libraries of aza-b-lactams.