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The synthesis of aza-β-lactams via tandem Petasis–Ugi multi-component condensation and 1,3-diisopropylcarbodiimide (DIC) condensation reaction

✍ Scribed by Dinabandhu Naskar; Amrita Roy; William L. Seibel; Laura West; David E. Portlock

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
309 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthetic utility of a tandem Petasis-Ugi multi-component condensation and 1,3-diisopropylcarbodiimide condensation reactions have been employed to efficiently prepare two to four-dimensional libraries of aza-b-lactams.

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Solid-phase synthesis of five-dimensiona
Solid-phase synthesis of five-dimensional libraries via a tandem Petasis–Ugi multi-component condensation reaction
✍ David E. Portlock; Dinabandhu Naskar; Laura West; Ryszard Ostaszewski; Jack J. C 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 254 KB

Five-dimensional libraries of dipeptide amides are readily prepared using a solid-phase tandem Petasis-Ugi multi-component condensation protocol on either a RINK amine or Universal RINK isonitrile resin. The method is practical and can be automated to prepare a large number of compounds useful for h