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Solid-phase synthesis of five-dimensional libraries via a tandem Petasis–Ugi multi-component condensation reaction

✍ Scribed by David E. Portlock; Dinabandhu Naskar; Laura West; Ryszard Ostaszewski; Jack J. Chen

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
254 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Five-dimensional libraries of dipeptide amides are readily prepared using a solid-phase tandem Petasis-Ugi multi-component condensation protocol on either a RINK amine or Universal RINK isonitrile resin. The method is practical and can be automated to prepare a large number of compounds useful for high throughput biological screening.

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