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Synthesis of selectively 15N- or 13C-labelled malachite green

โœ Scribed by Steven C. DeFina; Thorsten Dieckmann

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
107 KB
Volume
45
Category
Article
ISSN
0022-2135

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โœฆ Synopsis

Abstract

Two complimentary syntheses of selectively ^15^Nโ€ or ^13^Cโ€labelled malachite green hydrochloride were developed in order to provide labelled ligands for structural studies of RNA aptamer/ligand complexes. The ^15^Nโ€ and ^13^Cโ€labelled versions of the dye have been used in NMR studies to probe the changes in the electronic charge distribution and dynamics of the dye upon binding to RNA. Copyright ยฉ 2002 John Wiley & Sons, Ltd.

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