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Synthesis of labeled acrylamide and N-methylolacrylamide (NMA): 15N-acrylamide, 13C-NMA, 15N-NMA, and 13C,15N-NMA

✍ Scribed by N. R. Brown; C. E. Frazier

Publisher: John Wiley and Sons
Year: 2005
Tongue: French
Weight: 115 KB
Volume: 48
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1015

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✦ Synopsis

Labeled derivatives of N-methylolacrylamide (NMA) including 15 N-NMA, 13 C-NMA, and 13 C, 15 N-NMA were synthesized and purified. A required chemical precursor, 15 N-acrylamide, was also prepared. Reported methods for synthesizing unlabeled analogs are noted, and modifications to these methods for achieving the labeled materials are specified. Monomers were examined via 1 H, 13 C, and 15 N nuclear magnetic resonance (NMR) spectroscopy. Peak assignments and coupling constants are reported for each compound. To our knowledge, this is the first reported publication on the preparation and characterization of 13 C-NMA, 15 N-NMA, 13 C, 15 N-NMA, and 15 N-acrylamide.

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